• Posted July 30, 2026

Study Questions Effectiveness of Antihistamines in Easing Eczema

People with eczema often take antihistamine pills, hoping to ease relentless itching.

But a new study finds they may do little to help and could even cause worrisome side effects.

A team led by Dr. Alexandro Chu, of McMaster University in Hamilton, Canada, reviewed 47 clinical trials involving more than 6,200 children and adults with mainly moderate-to-severe eczema.

The trials compared antihistamines, H2 blockers and drugs called mast cell stabilizers to placebo — with and without standard treatments such as moisturizers or steroid creams. 

The results: Antihistamines produced only small, clinically unimportant improvements in eczema and itch severity, and did not seem to reduce sleep problems or flare-ups.

The researchers also warned that antihistamines probably increase drowsiness and sedation and may make patients more likely to stop treatment because of those side effects.

"Our findings do not support their use in routine atopic dermatitis [eczema] management," the authors write, although they noted that nearly half of eczema patients in the U.S. currently take antihistamine pills.

The researchers believe it's time for updated guidelines, ones that focus on what actually works, what's safe, and what patients really need.

More information

The National Eczema Association has more on treatments for eczema.

SOURCE: HealthDay TV, July 30, 2026